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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 1, 85-89, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE RELATION OF DRUG-INDUCED HYPOGLYCEMIA TO DUODENAL MOTILITY IN ANESTHETIZED DOGS

Ruben D. Bunag 1, Benjamin M. Rigor 1, Leonardo G. Tan-Gatue 1, William R. Reotutar 1, and Romulo Guevara 1

1 Department of Pharmacology, College of Medicine, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines

Duodenal motility was observed in anesthetized dogs following hypoglycemia induced by intravenous administration of insulin, carbutamide, tolbutamide or banaba. The duodenal motor response to insulin and banaba was consistent, a marked increase being observed in all animals tested. Changes in duodenal motility following intravenous injection of the arylsul-fonylureas were equivocal. A probable explanation for the difference is offered.

Submitted on July 1, 1959






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