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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 1, 41-43, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

DISAPPEARANCE OF VARIOUS DRUGS FROM THE CEREBROSPINAL FLUID

Steven E. Mayer 1, Roger P. Maickel 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Studies in rabbits of the disappearance of various drugs introduced into the CSF indicate that the substances pass the boundary from CSF to blood stream by a route which differs from the blood-CSF barrier, in that it permits the ready passage of poorly lipid-soluble substances. The relatively rapid disappearance of polar substances from the CSF, presumably through the arachnoid villi, may explain why drugs that slowly enter the CSF from the blood stream fail to attain a CSF/plasma distribution ratio of 1.0.

Submitted on July 6, 1959






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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.