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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 4, 268-275, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

STUDIES CONCERNING THE PRESENCE OF 5-HYDROXYTRYPTAMINE (SEROTONIN) IN THE PERFUSATE FROM THE SUPERIOR CERVICAL GANGLION

S. B. Gertner 1, M. K. Paasonen 1, and N. J. Giarman 1

1 Departments of Pharmacology, College of Physicians & Surgeons, Columbia University, and School of Medicine, Yale University

Serotonin (5-hydroxytryptamine, 5-HT) has been demonstrated in the perfusate from the functioning superior cervical ganglion of the cat in situ.

5-HT appeared in the effluent from the ganglion after 2 hours when iproniazid, a monoamine oxidase inhibitor, was added to the perfusion fluid.

Perfusion with 5-hydroxytryptophane, the precursor of 5-HT, together with iproniazid led to the appearance of 5-HT within 5 minutes.

The appearance of 5-HT in the effluent in either case was not dependent upon stimulation of the cervical sympathetic trunk. Once 5-HT began to appear, it continued to appear regardlss of nerve stimulation.

The implications of these findings to the transmission process are discussed.

Submitted on June 20, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.