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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 3, 191-194, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF VARIOUS MITOTIC INHIBITORS ON OXIDATIVE PHOSPHORYLATION AND AMINO ACID INCORPORATION

Sydney Spector 1 and Kwang Soo Lee 1

1 Department of Pharmacology, Jefferson Medical College, Philadelphia, Pa.

The effects of urethan, colchicine and HN2 on the oxidative phosphorylation of rat liver mitochondria were studied and it was found that these agents have no significant uncoupling action in concentrations effective in vivo.

The incorporation of labeled methionine in ascites tumor cells was inhibited by these agents in concentrations which inhibit mitosis. However, these agents did not inhibit the amino acid entrance into the cells.

Submitted on April 9, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.