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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 3, 178-181, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF MONOAMINE OXIDASE INHIBITORS AND TRYPTOPHAN ON THE TRYPTAMINE CONTENT OF ANIMAL TISSUES AND URINE

Sidney M. Hess 1, Betty G. Redfield 1, and Sidney Udenfriend 1

1 Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland

There is a significant increase in the tryptamine content of guinea pig tissues following administration of L-tryptophan alone and a much larger increase following the administration of the monoamine oxidase inhibitor, iproniazid. However, the increase in tissue tryptamine concentration is greatest when L-tryptophan is administered following pretreatment with iproniazid. The effects of L-tryptophan-iproniazid treatment on the tissue tryptamine levels of several other animal species were found to be comparable to those observed in the guinea pig. The increased tissue levels and excretion of tryptamine following the administration of iproniazid are evidence that there is probably a high turnover of tryptamine normally occurring in the body. The significance of these findings in relation to the mechanism of action of monoamine oxidase inhibitors is discussed.

Submitted on June 15, 1959




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G. K. Aghajanian and I. M. Asher
Histochemical Fluorescence of Raphe Neurons: Selective Enhancement by Tryptophan
Science, June 11, 1971; 172(3988): 1159 - 1161.
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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.