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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 2, 96-102, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE MECHANISM OF SEROTONIN AND CATECHOLAMINE UPTAKE BY PLATELETS

F. Barbara Hughes 1 and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Attempts to demonstrate the existence of a serotonin complex in suspensions of lysed rabbit platelets have not been successful. However, kinetic studies of serotonin uptake by platelets of normal and reserpine-treated guinea pigs indicate that serotonin is taken up by active transfer. Reserpine appears to act by blocking the active transport.

Norepinephrine and epinephrine, but not bufotenine, can also be taken up in platelets in vitro by a process which is blocked by reserpine.

Submitted on April 27, 1959




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K. H. Berneis, M. D. Prada, and A. Pletscher
Micelle Formation between 5-Hydroxytryptamine and Adenosine Triphosphate in Platelet Storage Organelles
Science, August 29, 1969; 165(3896): 913 - 914.
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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.