JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bowman, E. R.
Right arrow Articles by McKennis, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bowman, E. R.
Right arrow Articles by McKennis, H., Jr.
Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 2, 92-95, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF NICOTINE IN THE HUMAN AND EXCRETION OF PYRIDINE COMPOUNDS BY SMOKERS

Edward R. Bowman 1, Lennox B. Turnbull 1, and Herbert McKennis Jr. 1

1 Department of Pharmacology, Medical College of Virginia, Richmond

Following the smoking of tobacco or ingestion of nicotine the urine of human subjects contained cotinine which was identified as the picrate and dipicrate. Chromatograms of the urines suggest the presence of hydroxycotinine and desmethylcotinine and related Koenig positive components and lead to the conclusion that cotinine plays, in man as well as in the dog, an important role as intermediate in nicotine metabolism.

Submitted on April 7, 1959




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
J. Hukkanen, P. Jacob III, and N. L. Benowitz
Metabolism and Disposition Kinetics of Nicotine
Pharmacol. Rev., March 1, 2005; 57(1): 79 - 115.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.