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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 2, 167-170, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF 2-DIMETHYLAMINOETHANOL (DEANOL) ON ANAPHYLACTOID EDEMA IN RATS

Georg E. Cronheim 1 and I. M. Toekes 1

1 Research Division, Riker Laboratories, Northridge, California

2-Dimethylaminoethanol (deanol) had an inhibitory action on the anaphylactoid edema produced in rat paws by subplantar injection of eggwhite, serotonin, formaldehyde or histamine. The effect could be demonstrated acutely by intraperitoneal injection and, after a time lag, also by chronic oral administration. Presence of the adrenals was not required. The drug was ineffective in the cotton pellet granuloma type of inflammatory reaction.

Submitted on April 2, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.