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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 2, 164-166, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

DEVELOPMENT OF A RESISTANCE TO SODIUM PENTOBARBITAL IN RATS FED ON A DIET CONTAINING CHLORCYCLIZINE HYDROCHLORIDE

Ian D. Thompson 1, William C. Dolowy 1, and W. H. Cole 1

1 Department of Surgery and the Animal Hospital, University of Illinois, College of Medicine, Chicago, Illinois

Chlorcyclizine HCl, added to the diet of rats, caused no outward change in their behavior, but induced a resistance to sodium pentobarbital anesthesia evidenced by shortening of the recovery time and a resistance to sodium pentobarbital toxicity evidenced by a significant increase in the LD50.

Chlorcyclizine HCl has a sedative effect in small doses, but a convulsive effect in large doses, when injected intraperitoneally into rats; however, intraperitoneal injections of the drug did not affect the recovery time from pentobarbital anesthesia. Intravenous and intramuscular injections of chlorcyclizine did not increase the resistance of the rats to intraperitoneal injections of pentobarbital injected 30 minutes later.

Possible mechanisms whereby chlorcyclizine induces a resistance to the depressant action of pentobarbital are discussed.

Submitted on April 23, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.