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Journal of Pharmacology And Experimental Therapeutics, Vol. 127, Issue 2, 157-163, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE CENTRAL ACTION OF GANGLIONIC BLOCKING AGENTS

Robert Murray 1, Lloyd Beck 1, P. A. Rondell 1, and David F. Bohr 1

1 Department of Physiology and Pharmacology, University of Michigan, Ann Arbor, Michigan

The cross-circulated dog head preparation has been used to determine whiether TEA, hexamethonium, azamethonium, chlorisondamine or mecamylamine depresses blood pressure by an action on central mechanisms. Doses of these compounds which produced ganglionic blockade in the donor-isolated head system did not significantly affect recipient body blood pressure.

Technical and theoretical limitations of the cross-circulated head preparation as used in assessing the central action of ganglionic blocking agents are evaluated.

Submitted on May 4, 1959






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