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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 4, 345-348, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF CHRONIC MORPHINE ADMINISTRATION ON TOOTH PULP THRESHOLDS IN DOGS

H. H. Keasling 1, E. G. Gross 1, F. A. D. Alexander 1, Charles Hirschler 1, and Lawrence Marshall 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

The effects of chronic morphine administration on tooth pulp thresholds in dogs have been studied.

Morphine sulfate, 3 mg/kg, t.i.d., loses the property of raising the tooth pulp threshold with time. After 16 days essentially no response was observed. Doubling the dose gave increased response only on the first dose. Subsequent 6 mg/kg doses and 12 mg/kg doses were ineffective. Following 25 days of chronic administration no threshold increase was obtained with 24 mg/kg in either animals treated with 3 mg/kg, t.i.d., or those given the increasing doses. This dose, however, gave an increased response in animals given 3 mg/kg intermittently.

Submitted on March 5, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.