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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 4, 334-337, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON ACORUS CALAMUS (IV): INVESTIGATIONS ON MECHANISM OF ACTION IN MICE

P. C. Dandiya 1, H. Cullumbine 1, and E. A. Sellers 1

1 Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada

Pretreatment of mice with lysergic acid diethylamide partly prevents the hypnotic potentiating action of Acorns oil.

In iproniazid-treated mice, Acorus oil causes a fair degree of stimulation instead of sedation, noticed in untreated mice.

The hypnotic potentiating action of Acorus oil is not a result of its hypothermic action. Reserpine does not prolong pentobarbital sleeping time, if the body temperature is not allowed to fall. The hypothermic action of chlorpromazine is only partly responsible for its hypnotic potentiating action.

Submitted on April 7, 1959






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