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1 Department of Pharmacology, University of Louisville, School of Medicine, Louisville, Kentucky
Hippuric acid and 33 related substances have been studied in the dog for their manner of renal excretion and their influence on renal tubular transport of p-aminohippurate. Hippuric acid is excreted by the renal tubule and exhibits quantitative competition with p-aminohippurate. Of the related substances, tubular excretion occured only with those containing the carhoxyl and a benzamido or benzimido group. Substituation in the phenyl of the benzamido group may reduce the tubular excretion. Substances with a carboxyl and also a carbonyl-or-imino group but lacking a benzamido or -imido group did not undergo tubular excretion. The spatial separation of the carhoxyl and benzamido groups is not critical for transport until a certain distance is exceeded. Many of the substances found not to undergo tubular excretion had a depressant action on transport of p-aminohippurate.
Submitted on March 5, 1959
This article has been cited by other articles:
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  W. Geng and K. S. Pang Differences in Excretion of Hippurate, as a Metabolite of Benzoate and as an Administered Species, in the Single-Pass Isolated Perfused Rat Kidney Explained J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 597 - 606. [Abstract] [Full Text]
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