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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 4, 291-295, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF PROBENECID, SODIUM SALICYLATE, 2,4-DINITROPHENOL AND PYRAZINAMIDE ON RENAL SECRETION OF URIC ACID IN CHICKENS

Bohdan R. Nechay 1 and Laryssa Nechay 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

Probenecid was found to diminish renal tubular secretion of uric acid and to raise markedly plasma urate concentrations in the chicken.

Sodium salicylate and 2, 4-dinitrophenol inhibition were less effective, but also reduced uric acid excretion. The 2, 4-dinitrophenol effect suggests that the tubular transport of uric acid may be dependent on energy supplied by oxidative phosphorylation.

Since probenecid and sodium salicylate have previously been shown to inhibit reabsorption of uric acid in mammals, it is possible that there is a common factor in the transport mechanism for reabsorption and secretion of this substance.

Pyrazinamide was without effect on uric acid clearance in this species.

Submitted on March 12, 1959




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