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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 3, 258-263, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

SUBSTANCE A: A HYPERTENSIVE POLYPEPTIDE FROM FRACTION IN-4 OF PLASMA PROTEIN

E. J. Walaszek 1 and C. G. Huggins 1

1 Department of Pharmacology, Kansas University of Medical Center, Kansas City, Kansas

This report is concerned with a pharnmacologically active polypeptide, provisionally designated as substance. A, which was produced by incubation of fraction iv-4 of plasma protein with agramylase prepartions. A partially purified standard preparations. A partially purified of the active material upon charcoal and its subsequent elution with glacial acetic acid. The pharmacological Properties and some chemical properties of this standard preparation are described. A chemical and pharmacological comparison with other known polypeptides led to the conclusion that substance A was very similar to angiotomsin.

Submitted on February 11, 1959






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