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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 3, 195-201, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF THE RENAL TUBULAR TRANSPORT CHARACTERISTICS OF N1-METHYLNICOTINAMIDE AND TETRAALKYLAMMONIUM COMPOUNDS IN THE AVIAN KIDNEY

R. E. Green 1, W. E. Ricker 1, W. L. Attwood 1, Y. S. Koh 1, and Lawrence Peters 1

1 Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas

The evidence presented indicates that N1 methylnicotinamide (NMN), tetramethylammonium, tetraethylammonium and tetrabutylammonium are excreted by the same renal tubular transport system in the chicken.

A large number of tetraalkylammonium derivatives and a number of aliphatic amines are capable of inhibiting the tubular transport of NMN when infused simultaneously with NMN into the renal portal circulation of the chicken. The inhibitor potency of these compounds increased progressively as the length of the alkyl substituents on the nitrogen was increased.

Submitted on January 15, 1959




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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.