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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 3, 190-194, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF THE RENAL TUBULAR TRANSPORT OF N1-METHYLNICO-TINAMIDE (NMN) BY 1 ,1-DIALKYLPIPERIDINIUM COMPOUNDS IN THE AVIAN KIDNEY

R. L. Volle 1, C. G. Huggins 1, G. A. Rodriguez 1, and Lawrence Peters 1

1 Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas

Mepiperphenidol (Darstine) was shown to be excreted by the renal tubules of the chicken and to be a potent inhibitor of the simultaneous tubular transport of N1-methylnicotinamide (NMN). Among a number of 1-alkyl-1-methyl-piperidinium compounds, the ability to inhibit NMN transport increased progressively as the length of the carbon chain of one alkyl substituent was increased.

Submitted on January 15, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.