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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 179-184, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGICAL ACTIONS OF SUPININE AND LASIOCARPINE

Charles L. Rose 1, Paul N. Harris 1, and K. K. Chen 1

1 The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

Two pyrrolizidine alkaloids, supinine and lasiocarpine, have been investigated pharmacologically. In confirmation of our previous results in mice and rats, a single intravenous injection of lasiocarpine was followed by acute necrosis of the liver of golden hamsters and a rhesus monkey. Hypoprothrombinemia occurred in rats injected with lasiocarpine. Single intravenous injections of supinine, on the other hand, had no hepatotoxic action in mice and rats. This alkaloid appeared to have a very weak atropine-bike action.

Submitted on November 29, 1958






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