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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 176-178, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF PILOCARPINE ON INTRACELLULAR DISTRIBUTION OF CALCIUM IN RAT SUBMANDIBULAR GLAND

Robert H. Dreisbach 1

1 Department of Pharmacology, Stanford University School of Medicine, Stanford, California

Analysis of fractions separated by differential centrifugation from submandibular gland reveals that the fall in gland calcium induced by the administration of pilocarpine is explained bychanges in the most easily sedimentable fraction (400 x g) and in the supernatant fraction. Whereas the total gland calcium fell 31% after pilocarpine, the 400 x g fraction fell 54% and the supernatant fraction fell 41%. Although the total gland nitrogen did not change, the amount in the 400 x g fraction fell appreciably and all other fractions rose.

Submitted on January 12, 1959






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.