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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 174-175, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

CANINE ERYTHROCYTE CHOLINESTERASE ACTIVITY IN CHRONIC TABUN INTOXICATION

F. N. Craig 1

1 Applied Physiology Branch, U. S. Army Chemical Warfare Laboratories, Army ChemicalCenter, Maryland

In a series of 5 dogs given dimetluylamide-ethoxyphosphorylcyanide (tabun) by intramuscularinjection in divided doses over a period of 10 weeks, the remaining activity of the cholinesterase of the erythrocytes could be accounted for by the rate of administration of tabun, the irreversibility of the reaction with tabun and the continual regeneration of erythrocytes with a life span of 100 days.

Submitted on December 11, 1958






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.