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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 164-167, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF A NEW DRUG, N-(2-ENDOBICYCLO-(2,2,1)-HEPTANE)-DIETHYL-AMINOACETAMIDE HYDROCHLORIDE (ERL-239), ON MEAN ARTERIAL BLOOD PRESSURE, CARDIAC OUTPUT, CORONARY BLOOD FLOW, CARDIAC OXYGEN CONSUMPTION, WORK AND EFFICIENCY

René Wégria 1, J. Nakano 1, J. C. McGiff 1, Tatiana Muraviev 2, H. Zekert 1, and M. R. Blumenthal 1

1 Department of Medicine, Columbia University College of Physicians and Surgeons andthe Presbyterian Hospital, New York City
2 Department of Medicine, Columbia University College of Physicians and Surgeons an the Presbyterian Hospital, New York City

In the anesthetized dog, N-(2-endobicyclo- (2,2,1)-heptane)-diethylaminoacetamide hydrochloride (ERL-239) administered intravenously resulted in an increase of coronary blood flow. This increase occurred with doses which left the arterial blood pressure unchanged, with doses which lowered the arterial blood pressure only slightly and with doses which lowered the arterial blood pressure markedly. Cardiac output and work remained unchanged or decreased, cardiac oxygen consumption increased except with very large doses of the drug and cardiac efficiency always decreased.

Submitted on December 8, 1958






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.