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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 158-163, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGICAL EFFECTS OF SOME CONGENERS OF 2-AMINO-ETHYLISOTHIURONIUM BROMIDE (AET)

Victor Distefano 1, Daniel E. Leary 1, and Katharine Davis Little 1

1 Department of Pharmacology, The University of Rochester, School of Medicine and Dentistry, Rochester, New York

The pharmacological effects of some AET derivatives are discussed and compared with those ofthe parent compound. APT behaves quantitatively and qualitatively like AET. 2-AT retains some of the characteristics of its parent compound. ABT bears no pharmacological relationship to the others.

The actions of AET, APT and some of the actions of 2-AT are attributed to the presence of a free sulfhydryl group.

ABT, which cannot form a free sulfhydryl, is relatively inactive pharmacologically and bearsno pharmacological relation to its parent compound, AET.

Submitted on January 17, 1959






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