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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 136-142, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

A METHOD FOR ANALYZING THE EFFECT OF pH AND THE IONIZATION OF DRUGS UPON CARDIAC TISSUE WITH SPECIAL REFERENCE TO PENTOBARBITAL

Harold F. Hardman 1, Joanne I. Moore 1, and Bert K. B. Lum 1

1 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan

A method employing the isolated perfused turtle heart as a test system for examining the effects of pH and drug ionization upon cardiac tissue over a wide pH range has been described.

The degree of negative inotropic activity observed with sodium pentobarbital in the isolatedperfused turtle and rabbit heart is directly proportional to the concentration of unionized pentobarbital present in the perfusion medium.

The ionized form of pentobarbital (anion) did not exhibit any negative inotropic activity inthe isolated perfused turtle and rabbit heart in any of the concentrations tested.

The original hypothesis of Clowes et al. (1940) concerning the depressant action ofseveral barbiturates on arbacia eggs has been found applicable to the action of pentobarbital on turtle and rabbit cardiac tissue within a restricted pH range.

Submitted on December 26, 1958






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