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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 131-135, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

N-ACETYL-DL-PENICILLAMINE, A NEW ORAL PROTECTIVE AGENT AGAINST THE LETHAL EFFECTSOF MERCURIC CHLORIDE

H. Vasken Aposhian 1 and Mary M. Aposhian 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

A new oral agent, N-acetyl-DL-penicillamine, effective in protecting rats against the lethaleffects of mercuric chloride, is described. This compound is more effective than either D-penicillamine or DL-penicillamine in this respect. Data are presented on the toxicity in the rat ofthese orally effective sulfhydryl compounds, indicating that N-acetyl-DL-penicillamine and D-penicilamine are less toxic than DL-penicillamine.

Submitted on January 2, 1959




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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.