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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 2, 117-122, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE HEPATIC EXCRETION OF DIGITALIS GLYCOSIDES AND THEIR GENINS IN THE RAT

Elizabeth Cox 1 and S. E. Wright 1

1 Department of Pharmacology and Pharmacy, University of Sydney, Sydney, Australia

The biliary excretion of lanatoside A, lanatoside C, digitoxin, digoxin, digitoxigenin and digoxigenin in rats has been examined by paper chromatographic and colorimetric methods.

In bile lanatosides A and C were excreted unchanged. Digitoxin, digoxin and digoxigenin were present partly unaltered and partly as metabolites which still retained the unsaturated lactone ring. Digitoxigenin was excreted entirely as metabolites.

The amount of glycoside or aglycone and their metabolites present in the bile within 5 hours of glycoside administration was determined. This ranged from 70 to 80% of the dose for lanatosides A and C to about 10% for digitoxin. About 15% of the dose of each aglycone was excreted in bile.

The relationship between the biliary excretion and the structure of these substances is discussed.

Submitted on November 22, 1958






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.