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Journal of Pharmacology And Experimental Therapeutics, Vol. 126, Issue 1, 70-75, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

SOME ASPECTS OF THE METABOLISM OF ALCOHOL IN VITRO

Thomas N. Burbridge 1, V. C. Sutherland 1, Charles H. Hine 1, and Alexander Simon 1

1 Department of Pharmacology, University of California School of Medicine, San Francisco, and Langley Porter Nenropsychiatric Institute, California State Department of Mental Hygiene, San Francisco

A study in vitro indicates that the concentration of alcohol does influence the rate of metabolism by brain and liver. The data indicate that the metabolic system in brain differs from that of liver. The uptake of alcohol by brain was studied in the presence of various substrates. Glucose supported greater uptake than any of the others investigated. Ethanol only slightly decreases acetaldehyde uptake by brain in the presence of glucose, while acetaldehyde decreases ethanol uptake in the presence of a variety of substrates. Human brain differs from rat brain in regard to the influence of various substrates on alcohol uptake in vitro. Human brain is similar to rat brain in that pyruvate or acetaldehyde decreases its uptake of alcohol.

Submitted on November 12, 1958




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R. D. Myers
Alcohol Consumption in Rats: Effects of Intracranial Injections of Ethanol
Science, October 11, 1963; 142(3589): 240 - 241.
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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.