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Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 4, 347-352, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF BEMEGRIDE (MEGIMIDE) AND METRAZOL ON SOME NEURODEPRESSORS

Vicente Zapata-Ortiz 1, Ramiro Castro De La Mata 1, and Augusto Campos-Iturrizaga 1

1 Department of Pharmacology, Faculty of Medicine, San Marcos University, Lima, Peru

A study of the effects of beta-methyl-beta-ethylglutaramide (Megimide) in mice, rabbits and dogs indicate that Megimide is a convulsive agent similar to Metrazol.

Megimide acts as an antagonist to the depressant action of pentobarbital, urethane and ethyl alcohol in experimental animals.

The injection of subconvulsive doses of Meginude produces convulsions in dogs and mice that have received large doses of morphine.

Megimide is not a specific barbiturate antagonist since it will antagonize other neurodepressors unrelated in chemical structure to the barbiturates.

The data presented offers no evidence that Megimide is a better antagonist than Metrazol in acute barbiturate poisoning in animals.

Submitted on October 31, 1958






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.