JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McDonald, R. K.
Right arrow Articles by Patrick, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McDonald, R. K.
Right arrow Articles by Patrick, R. W.
Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 3, 241-247, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF MORPHINE AND NALORPHINE ON PLASMA HYDROCORTISONE LEVELS IN MAN

Roger K. McDonald 1, Franklin T. Evans 1, Virginia K. Weise 1, and Raymond W. Patrick 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Maryland

The effect of therapeutic doses of morphine and nalorphine on the plasma hydrocortisone levels of normal human subjects in different test situations is reported. Interpreting changes in plasma hydrocortisone concentration in terms of ACTH release, we conclude that the primary effect of therapeutic doses of morphine on early morning ACTH release in sedated, normal subjects is a suppressant one. In nonsedated subjects, morphine is capable of depressing midday ACTH release as well as ACTH release induced by a standardized stress (vasopressin).

The adrenals were shown to be at least normally responsive to injected ACTH after morphine administration.

The pertinence of these findings to the problem of mechanism of ACTH release is discussed.

Submitted on October 6, 1958




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Spies, V. Eggers, G. Szabo, A. Lau, V. von Dossow, H. Schoenfeld, H. Althoff, K. Hegenscheid, B. Bohm, T. Schroeder, et al.
Intervention at the Level of the Neuroendocrine-Immune Axis and Postoperative Pneumonia Rate in Long-term Alcoholics
Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 408 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. P. Desborough
The stress response to trauma and surgery
Br. J. Anaesth., July 1, 2000; 85(1): 109 - 117.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Engler, E. Redei, and I. Kola
The Corticotropin-Release Inhibitory Factor Hypothesis: A Review of the Evidence for the Existence of Inhibitory as Well as Stimulatory Hypophysiotropic Regulation of Adrenocorticotropin Secretion and Biosynthesis
Endocr. Rev., August 1, 1999; 20(4): 460 - 500.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.