JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, C. M.
Right arrow Articles by Urban, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, C. M.
Right arrow Articles by Urban, C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 3, 227-229, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

INTERACTION BETWEEN NEUROMUSCULAR BLOCKING AGENTS: TIME COURSE OF EFFECTS AS ASSESSED BY RABBIT HEAD-DROP ASSAY

Cedric M. Smith 1 and Conrad Urban 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois

The time course of the interaction between decamethonium or succinylcholine and tubocurarine was determined by the rabbit head-drop cross-over technique. Decamethonium pretreatment decreases the amount of tubocurarine required to produce head-drop for more than 2 hours to an even greater extent than does pretreatment with tubocurarine itself; decamethonium is synergistic with a decamethonium pretreatment but for only 50 to 80 minutes.

Tachyphylaxis was observed with succinylcholine administered 20 to 80 minutes after a prior succinylcholine head-drop. Succinylcholine pretreatment decreased the head-drop dose of tubocurarine determined 10 minutes later. Tubocurarine, when administered 10 minutes prior to succinylcholine, decreased the head-drop dose of succinylcholine.

Submitted on October 10, 1958






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.