THE EFFECT OF AZACYCLONOL ON SOME CARDIOVASCULAR AND METABOLIC ACTIONS OF EPINEPHRINE

¹ Department of Pharmacology, Scientific Laboratories, The Wm. S. Merrell Co., Cincinnati 15, Ohio

Quinidine and diphenylhydantoin, in doses which block epinephrine-induced cardiac arrhythmias, have been shown to have no effect on the concurrent hyperkalemia.

Procaine amide attenuated the hyperkalemia in 3 of 6 dogs, but had no effect in the remaining animals.

Azacyclonol, which has transient antiarrhythmia action, blocks or greatly attentuates hyperkalemia and partially inhibits the hyperglycemia resulting from the injection of large doses of epinephrine in anesthetized dogs. Experiments using blood pressure responses to sympathomimetic amines demonstrate that azacyclonol is not an adrenergic blocking agent of the Dibenamine or ergot type but may have some similarity to a known blocking agent of adrenergic inhibitory responses.