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Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 3, 198-201, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

URINARY METABOLITES OF SALICYLAMIDE IN STONE-FORMERS

William O. Foye 1, Ronald N. Duvall 1, Winthrop E. Lange 1, Montgomery H. Talbot 1, and Edwin L. Prien 1

1 Department of Chemistry, Massachusetts College of Pharmacy, Boston

By means of paper chromatography and comparison with known compounds, the urinary metabolites of salicylamide in stone-forming patients were investigated. Twelve selected cases, among a larger group, in which the dose of salicylamide was 2.0 to 3.6 g daily are reported. It was indicated that 46% of the salicylamide was excreted as glucuronide and 31% as the sulfate on the average. Also, free salicylamide appeared in 50% of the cases and salicyluric acid in 40% in undetermined amounts.

In general, the salicylamide glucuronide excreted was the ether, but a small amount of ester glucuronide was determined in patients with high glucuronide outputs. This was determined by differential hydrolyses.

Submitted on September 19, 1958






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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.