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Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 2, 178-183, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

A DIFFERENTIAL EFFECT OF RESERPINE ON PRESSOR AMINE ACTIVITY AND ITS RELATIONSHIP TO OTHER AGENTS PRODUCING THIS EFFECT

R. A. Maxwell 1, H. Povalski 1, and A. J. Plummer 1

1 Research Department, CIBA Pharmaceutical Products Inc., Summit, New Jersey

The blood pressure responses to a series of pressor amines of the phenylalkylamine type are altered following reserpine administration such that amines possessing "See image in the PDF file" or

See images in PDF file

are augmented or not affected, amines possessing "See image in the PDF file" are reversibly antagonized and amines possessing "See image in the PDF file" are irreversibly supressed. This "paradoxical" action of reserpine is discussed in relation to the other agents known to produce a similar action.

Submitted on August 13, 1958






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