JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roth, L. J.
Right arrow Articles by Barlow, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roth, L. J.
Right arrow Articles by Barlow, C. F.
Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 2, 128-136, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

SULFUR-35 LABELED ACETAZOLAMIDE IN CAT BRAIN

Lloyd J. Roth 1, Joseph C. Schoolar 1, and Charles F. Barlow 1

1 Department of Pharmacology and the Division of Neurology of the Department of Medicine, The University of Chicago, Chicago 37, Illinois

Combined radioassay and autoradiographic techniques have shown that acetazolamide enters selected areas of the brain in significant quantities. The drug occurs in brain, cerebrospinal fluid and plasma as unchanged acetazolamide.

Two portals of entry of acetazolamide into the brain are utilized. The early pattern is one of diffusion from the cerebrospinal fluid with those tissues having easy access to the cerebrospinal fluid showing the highest drug content. This early diffusional pattern from the cerebrospinal fluid becomes less distinct in time. The second route of entry is blood-to-brain transport.

The distribution of acetazolamide is not well correlated with the known pattern of vascularity in the brain. It is suggested that the early acetazoamide picture may represent in part a distribution in the interstitial fluid compartment. To this end experiments using the sulfate-S35 ion have been designed to measure the extracellular space.

Hippocampus, hypothalamus and caudate nucleus are areas of high acetazolamide uptake and show a discrete retention over contiguous areas. Whether or not this retention is a function of local chemical binding of the drug is a matter of speculation.

Submitted on August 11, 1958




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
D. E. Leaf and D. S. Goldfarb
Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness
J Appl Physiol, April 1, 2007; 102(4): 1313 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Mueggler, C. Sturchler-Pierrat, D. Baumann, M. Rausch, M. Staufenbiel, and M. Rudin
Compromised Hemodynamic Response in Amyloid Precursor Protein Transgenic Mice
J. Neurosci., August 15, 2002; 22(16): 7218 - 7224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. J. TEPPEMA and A. DAHAN
Acetazolamide and Breathing . Does a Clinical Dose Alter Peripheral and Central CO2 Sensitivity?
Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1592 - 1597.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.