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Journal of Pharmacology And Experimental Therapeutics, Vol. 125, Issue 2, 111-115, 1959
Copyright © 1959 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THE HYPOTHALAMUS IN PITUITARY-ADRENAL ACTIVATION AND ANTIDIURESIS BY MORPHINE

Robert George 1 and E. Leong Way 1

1 Department of Pharmacology, Schools of Pharmacy & Medicine, University of California, San Francisco, California

The importance of the hypothalamus as an intermediary in pituitary-adrenal activation and antidiuresis produced by morphine was established in studies on rats with hypothalamic lesions. Lesions of the median eminence completely blocked the adrenal ascorbic acid depletion which normally occurs 1 hour following the administration of morphine (30 mg/kg), in 11 of 13 animals. Partial lesions of the anterior median eminence, as well as lesions placed anterior and dorsal to the median eminence, did not alter the normal adrenal cortical response to morphine. Lesions of the hypothalamus which produced diabetes insipidus blocked the antidiuretic response of a small dose (0.1 mg/kg) but failed to inhibit the response to larger doses (1.0 to 10 mg/kg). It was concluded that ADH and ACTH release can be independently influenced by pharmacologic agents.

Submitted on August 18, 1958




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Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics.