ACTION OF TRICYCLAMOL SULFATE ON GASTRIC SECRETION OF RATS AND DOGS

¹ The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

In rats with chronic fistulas the basal secretion of gastric juice was inhibited by oral administration of 1 mg/kg of tricyclamol. The meal- and insulin-stimulated gastric secretion of the innervated and denervated gastric pouches of dogs were depressed by oral administration of tricyclamol in doses ranging from 1 to 2 mg of the free base/kg of body weight. This inhibition was manifested by a significant decrease in volume and in acid concentration.

Tricyclamol was less effective on histaminestimulated gastric secretion. At 1 to 1.5 mg/kg significant reduction of volume and acid concentration was seen in some cases. It is concluded that tricyclamol principally abolishes the neurohumoral mechanism rather than the humoral mechanism (histamine or gastrin) of gastric acid secretion. The inhibition of meal-stimulated secretion is mainly, perhaps, due to the action of tricyclamol on the nervous aspect of the response complex.

The conditions for producing these effects have been discussed.