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Journal of Pharmacology And Experimental Therapeutics, Vol. 124, Issue 4, 282-289, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

DEGRADATION OF MESCALINE BY AMINE OXIDASES

E. Albert Zeller 1, James Barsky 1, Elaine R. Berman 1, Marshall S. Cherkas 1, and James R. Fouts 1

1 Department of Biochemistry, Northwestern University, Medical School, Chicago, Illinois

The oxidative deamination of mescaline by various tissue preparations from 9 vertebrate species was investigated. The mescaline oxidase of rabbit liver was found to be present in the mitochondrial and microsomal fractions of the cell. The inhibitor pattern for the rabbit liver enzyme resembled that characterizing a typical diamine oxidase (DO). Similar results were obtained for the oxidation of mescaline by a partially purified hog kidney DO (histaminase) and for sheep plasma spermine oxidase. These 3 enzymes are classified as belonging to the group of semicarbazide-sensitive diamine oxidases. The experimental evidence for the degradation of mescaline by particulate preparations from hog kidney and liver, and mouse liver, implicates the action of a semicarbazide-resistant monoamine oxidase in these species.

Submitted on July 7, 1958






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.