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Journal of Pharmacology And Experimental Therapeutics, Vol. 124, Issue 2, 182-187, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

HEART LESIONS IN MICE CAUSED BY TREATMENT WITH BISHYDROXYCOUMARIN (DICUMAROL)

F. I. Dessau 1, S. Klein 1, L. Lipchuck 1, J. O'Grady 1, and J. Tsalikis 1

1 Department of Experimental Pathology, Experimental Therapeutics Research Section, Research Division, American Cyanamid Company

Dicumarol added to either purified, or pellet diets, at levels from 40 to 200 mg/kg diet, induced heart muscle lesions in mice resembling those observed in mice kept on sulfaguanidine-supplemented purified diets.

Vitamin E supplements to the diet did not modify the effect of Dicumarol (200 mg/kg), while this effect was prevented by vitamin K1 at 2 times, or Menadione at 8 times the dietary level of Dicumarol.

The addition of vitamin E to a diet containing Menadione at twice the level of Dicumarol did not alter the effect of Dicumarol.

Submitted on May 5, 1958






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.