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Journal of Pharmacology And Experimental Therapeutics, Vol. 124, Issue 1, 94-96, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

A MINIMUM ERROR TABLE FOR PARALLEL LINE BIOLOGICAL ASSAYS

Mindel C. Sheps 1 and Katharine H. Hendrie 1

1 Department of Preventive Medicine, Harvard University Medical School, Boston, Massachusetts

The calculation of the index lgr in parallel line biological assays yields comparative information about the precision of the method. Further calculations and logarithmic transformations are needed to describe the minimum standard error of potency estimates derived in the assay with a given number of subjects, or alternatively to estimate the minimum number of assay subjects to achieve a desired minimum error.

The table presented in this paper obviates the need for such calculations. If shows directly the relationship between lgr, the number of assay subjects and the minimum standard error expressed as a per cent of a potency estimate. Examples are given of the use of the table.

Submitted on April 30, 1958






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