JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 124, Issue 1, 73-76, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

THE ANTI-TREMORINE EFFECT OF SOME DRUGS AS DETERMINED BY HAFFNER'S METHOD OF TESTING ANALGESIA IN MICE

Graham Chen 1

1 Research Laboratories, Parke, Davis & Company, Detroit, Michigan

Tremorine has been shown to produce analgesia in mice by Haffner's method. The Tremorine-induced analgesia may be antagonized by hyoscine, atropine, and other drugs effective against Parkinsonism. Nalorphine, desoxyephedrine, phenobarbital and numerous CNS stimulants and depressants are ineffective at minimal neurotoxic dose levels. Antagonism against Tremorine-induced analgesia, as determined by Haffner's method in mice, is suggested as a simple and reliable procedure for screening potential anti-Parkinsonism agents.

Submitted on May 29, 1958




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
J. L. Ellis, D. Harman, J. Gonzalez, M. L. Spera, R. Liu, T. Y. Shen, D. M. Wypij, and F. Zuo
Development of Muscarinic Analgesics Derived from Epibatidine: Role of the M4 Receptor Subtype
J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 1143 - 1150.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. Sheardown, H. E. Shannon, M. D. B. Swedberg, P. D. Suzdak, F. P. Bymaster, P. H. Olesen, C. H. Mitch, J. S. Ward, and P. Sauerberg
M1 Receptor Agonist Activity Is Not a Requirement for Muscarinic Antinociception
J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 868 - 868.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. E. Shannon, M. J. Sheardown, F. P. Bymaster, D. O. Calligaro, N. W. Delapp, J. Gidda, C. H. Mitch, B. D. Sawyer, P. W. Stengel, J. S. Ward, et al.
Pharmacology of Butylthio[2.2.2] (LY297802/NNC11-1053): A Novel Analgesic with Mixed Muscarinic Receptor Agonist and Antagonist Activity
J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 884 - 894.
[Abstract] [Full Text]

Home page
 ScienceHome page
B. Csillik
Tremorine: Its Peripheral Action on Striated Muscle
Science, November 6, 1964; 146(3645): 765 - 766.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.