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Journal of Pharmacology And Experimental Therapeutics, Vol. 124, Issue 1, 59-63, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

SOME CARDIOVASCULAR EFFECTS OF NORETHANDROLONE (NILEVAR), TESTOSTERONE AND PROGESTERONE

C. Gordon Van Arman 1 and Victor A. Drill 1

1 Division of Biological Research, G. D. Searle & Co., Chicago 80, Illinois

Norethandrolone (17-ethyl-19-nortestosterone), testosterone propionate and progesterone all depress the amplitude of contraction of the isolated perfused rabbit heart.

Norethandrolone has appreciable potency in abolishing auricular flutter in dogs. Progesterone is approximately as effective as norethandrolone in this regard. Testosterone propionate does not show such activity to the same extent as the other two steroids.

Norethandrolone does not affect ventricular arrhythmia caused by coronary occlusion. It has negligible effects On blood pressure, heart rate and electrocardiogram, even at very large doses.

Submitted on June 18, 1958






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.