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Journal of Pharmacology And Experimental Therapeutics, Vol. 123, Issue 4, 296-305, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGICAL ACTIONS OF RYANODINE IN THE MAMMAL

Leonard Procita 1

1 Department of Pharmacology, St. Louis University School of Medicine, St. Louis 4, Missouri

Some toxidological and pharmacological properties of ryanodine, a purified alkaloid derived from the South American plant Ryania speciosa Vahl, have been investigated in the cat, dog and to variety of other mammalian species.

Ryanodine has been shown to be to highly toxic compound to all species studied.

In the unanesthetized animal ryanodine produces an irreversible contracture of striated skeletal muscle and death may be attributed to a paralysis of the muscles of respiration.

In the anesthesized dog, however, ryanodime produces a hypotension and circulatory failure before the respiration is too severely embarrassed. Artificial respirtotion is of no value. On the other hand, in the anesthetized cat ryanodine usually produces a paralysis of the muscles of respiration before the circulation is irreversobly affected. In this animal artificial respiration will sustain the circulation for up to 5 hours, but failure will gradually ensue.

The origin of the hypotension produced in the cat and dog by ryanodine has not been exactly determined, but the experimental data existing to date suggest that both the hypotension and circulatory failure result from a direct effect of ryanodine on the cardiac muscle.

Submitted on May 12, 1958




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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.