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Journal of Pharmacology And Experimental Therapeutics, Vol. 123, Issue 3, 220-223, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF THE ANTIPRURITIC EFFECT OF MORPHINE AND PAPAVERINE IN EXPERIMENTAL AND PATHOLOGICAL ITCH IN MAN

Spyros G. MacRis 1, Gene M. Smith 1, and Henry K. Beecher 1

1 Anesthesia Laboratory of the Harvard Medical School at the Massachusetts General Hospital, Boston

The effect of papaverine, morphine, pentobarbital, aminophylline, tripelenamine and placebo was tested on experimental pruritus induced with cowhage. Only papaverine reduced experimental pruritus to a statistically significant degree.

Since papaverine has been shown in another study in this laboratory not to have analgesic power greater than that associated with placebos, this raises some question about the theory that the same apparatus mediates itch and pain.

Submitted on March 10, 1958






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