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Journal of Pharmacology And Experimental Therapeutics, Vol. 123, Issue 3, 193-205, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

DIFFERENTIAL EFFECTS ON VARIOUS CONDITIONED RESPONSES IN CATS CAUSED BY INTRAVENTRICULAR AND INTRAMUSCULAR INJECTIONS OF RESERPINE AND OTHER SUBSTANCES

E. Roy John 1, Bernice M. Wenzel 1, and R. D. Tschirgi 1

1 Departments of Physiology and Anatomy, School of Medicine, University of California at Los Angeles

Cats were trained to avoid shock on the presentation of either an auditory or a visual cue, to perform pattern discriminations for food, and to obtain visible food on an elevated runway. The effects of intraventricular and systemic administration of various substances, singly and in combination, were then studied on these responses.

Reserpine, injected either centrally or peripherally, attenuated avoidance responses while leaving approach responses relatively unaffected with the peripheral route more effective. At sufficiently low doses, it was possible to block visually cued avoidance responses, leaving both avoidance responses to auditory cues and approach responses unaffected. This was interpreted as evidence for a specific action of reserpine on the learned association between the visual stimulus and the evasion response.

The interactions of serotonin, iproniazid, epinephrine, norepinephrine and atropine injected centrally and, in some cases, peripherally, with reserpine were studied. Although some of these substances altered the autonomic effects of reserpine, only epinephrine appeared to attenuate the effects of reserpine on the conditioned behavior.

Methamphetamine consistently completely reversed the effects of reserpine when injected peripherally but central injection of methamphetamine did not reverse the reserpine-induced block of conditioned avoidance responses as effectively, although the autonomic effects of reserpine were reversed.

The implications of these findings are discussed.

Submitted on February 20, 1958




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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.