JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mark, L. C.
Right arrow Articles by Brodie, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mark, L. C.
Right arrow Articles by Brodie, B. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 123, Issue 1, 70-73, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

THE PASSAGE OF THIOBARBITURATES AND THEIR OXYGEN ANALOGS INTO BRAIN

Lester C. Mark 1, J. J. Burns 1, Leonard Brand 1, C. Ines Campomanes 1, Natalie Trousof 1, E. M. Papper 1, and Bernard B. Brodie 1

1 Department of Anesthesiology, Columbia-Presbyterian Medical Center, and New York University Research Service, Goldwater Memorial Hospital, New York City and the Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Thiobarbiturates pass into brain more rapidly than do their oxygen analogs. This is probably due to their higher lipid solubility, rather than to any specific effect of the sulfur-substitution in the molecule.

Submitted on December 16, 1957




This article has been cited by other articles:


Home page
 ScienceHome page
L. Huang and J. Barker
Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons
Science, January 11, 1980; 207(4427): 195 - 197.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.