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Journal of Pharmacology And Experimental Therapeutics, Vol. 123, Issue 1, 22-27, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

STUDIES CONCERNING THE CARDIOVASCULAR ACTIONS OF THE CENTRAL NERVOUS STIMULANT, METHYLPHENIDATE

H. A. Maxwell 1, A. J. Plummer 1, S. D. Ross 1, and A. I. Daniel 1

1 Research Department, CIBA Pharmaceutical Products Inc., Summit, New Jersey

The complex of antihypertensive activities exhibited by methylphenidate is explained only in part by effects elicited in the efferent periphery. The blocking effect of methylphenidate on amphetamine hypertension has a distinct efferent peripheral component. The antagonizing effect of methylphenidate on carotid occlusion reflex pressor responses cannot be explained by an obvious afferent or efferent peripheral blockade. The moderate antihypertensive effect of methylphenidate in the renal hypertensive dog cannot be explained by a blocking effect on the rerin pressor system.

Submitted on January 29, 1958






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.