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Journal of Pharmacology And Experimental Therapeutics, Vol. 122, Issue 3, 396-405, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF AMINOPHYLLINE AND OTHER XANTHINES ON THE PULMONARY CIRCULATION

Charles W. Quimby Jr. 1, Domingo M. Aviado Jr. 1, Carl F. Schmidt 1, and Sage E. Rosen 1

1 Laboratory of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia

The intravenous injection of aminophylline in anesthetized dogs usually caused a fall in pulmonary arterial pressure. The major cause for this hypotensive response is local vasodilatation, demonstrable in the perfused lungs. This is not the exclusive action of aminophylline because the minimum effective intravenous dose that reduces pulmnonary arterial pressure also produces increased pulmonary blood flow, increased force of myocardial contraction and aortic hypotension. Testing of 40 xanthine derivatives revealed similar vasodilatation or vasoconstriction for the lungs and extremities, but never selective pulmonary vasodilatation.

Submitted on September 26, 1957






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.