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Journal of Pharmacology And Experimental Therapeutics, Vol. 122, Issue 3, 370-378, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

NARCOTIC POTENCY AND SIDE EFFECTS OF ANILERIDINE AND MEPERIDINE IN MAN

Francis F. C. Chang 1, Peter Safar 1, and Louis Lasagna 1

1 Department of Anesthesiology, Baltimore City Hospitals, and Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University School of Medicine, Baltimore, Maryland

A method for studying narcotic potency in man is presented, utilizing the ability of narcotic drugs to reinforce nitrous oxide analgesia under controlled experimental conditions.

A new synthetic narcotic and analgesic drug, anileridine, was studied in comparison with meperidine.

Our studies indicate that anileridine is a potent narcotic, which is not superior to meperidine. It produces respiratory depression and subjective side effects of a magnitude and with a frequency at least as great as seen after meperidine when both drugs are given in equipotent doses. The human data thus far available contrast dramatically with the reported superiority of anileridine in animals.

Submitted on October 4, 1957






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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.