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Journal of Pharmacology And Experimental Therapeutics, Vol. 122, Issue 3, 295-300, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

IDENTIFICATION AND CHEMICAL ASSAY OF NOREPINEPHRINE IN BRAIN AND OTHER TISSUES

Parkhurst A. Shore 1 and Jacqueline S. Olin 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland

Norepinephrine has been identified chemically as a normal constituent of brain.

A simple, rapid fluorometric method for the estimation of catechol amines in brain and other tissues is described.

The procedure involves extraction of catechol amines from tissue homogenates into butanol. After returning the amines to an aqueous phase, they are oxidized to form fluorescent derivatives which are measured in a spectrofluorometer.

Submitted on September 26, 1957




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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.