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Journal of Pharmacology And Experimental Therapeutics, Vol. 122, Issue 2, 195-200, 1958
Copyright © 1958 by American Society for Pharmacology and Experimental Therapeutics

THE PYRETOGENIC EFFECT OF 5-HYDROXYTRYPTOPHAN AND ITS COMPARISON WITH THAT OF LSD

Akira Horita 1 and John H. Gogerty 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle

5-Hydroxytryptophan administered to rabbits produces a pynetogenic response which is roughly proportional to the dose administered. Iproniazid potentiates this response markedly, indicating that serotonin is the agent directly responsible for the effect.

Both the LSD and 5HTP pyretogenic effects are greatly attenuated by prior administration of BOL, the bromine analogue of LSD. This block appears to be quite specific and is competitive in nature.

After tolerance is developed in rabbits by daily injections of progressively increasing doses of LSD the usual 5HTP pyretogenic response is greatly diminished, presumably due to a cross tolerance phenomenon.

These experiments suggest that the LSD pyretogenic effect is similar to that produced by high brain levels of serotonin.

Submitted on September 21, 1957




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Copyright © 1958 by the American Society for Pharmacology and Experimental Therapeutics.