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Journal of Pharmacology And Experimental Therapeutics, Vol. 121, Issue 4, 443-448, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

BIOCHEMORPHOLOGY OF RENAL TUBULAR TRANSPORT: HALOGENATED AMINO ACIDS AND DERIVATIVES

K. C. Huang 1 and P. K. Knoefel 1

1 Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky

Eleven halogenated amino acids and derivatives have been studied for binding to plasma protein and renal tubular transport. Tubular secretion was found to occur with diiodotyrosine and its diacetyl, N-acetyl, and N-carboxymethyliminocarbonyl derivatives. Tubular reabsorption occurred with N-2-iodophenyl-agr-alanine, N-2,4-diiodophenyl-beta-alanine, N-carbethoxy-diiodotyrosine, N-benzoyl-diiodotyrosine, S-4-bromobenzyl-cysteine, and N-acetyl-S-4-bromobenzyl-cysteine. N-2,3,5-triiodobenzoyl-tyrosine was neither absorbed nor excreted. None of the compounds were of value for Roentgen visualization of the urinary system.

Submitted on July 18, 1957






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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.